' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folic acid improves angina symptoms
Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
Study directly assesses folic acid
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Read More
7
Folate's mixed effects on angina
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Lower relevance due to complexity
We explored the effects of folate treatment on a woman diagnosed with stable angina and a history of miscarriages, driven by hyperhomocysteinemia linked to the MTHFR C677T polymorphism. Her condition raised questions about whether supplementing with folic acid, along with vitamins B6 and B12, could alleviate her chest pain and improve her overall health.
Upon starting this combined treatment, we observed a notable 28.6% decrease in her homocysteine levels within two months. While this might suggest a positive trend towards her cardiovascular health, it's essential to highlight that despite the initial improvements, evidence regarding the long-term benefits of folate supplementation specifically for reducing chest pain has yet to be established.
Thus, while the vitamins showed effectiveness in lowering homocysteine levels, their role in significantly preventing future cardiovascular events remains uncertain. We acknowledge that further research will be necessary to better understand the broader implications of folate and its potential impact on conditions like angina and the associated risks.
Upon starting this combined treatment, we observed a notable 28.6% decrease in her homocysteine levels within two months. While this might suggest a positive trend towards her cardiovascular health, it's essential to highlight that despite the initial improvements, evidence regarding the long-term benefits of folate supplementation specifically for reducing chest pain has yet to be established.
Thus, while the vitamins showed effectiveness in lowering homocysteine levels, their role in significantly preventing future cardiovascular events remains uncertain. We acknowledge that further research will be necessary to better understand the broader implications of folate and its potential impact on conditions like angina and the associated risks.
Read More
Most Useful Reviews
9.5
Guaranteed regularity
After starting folate on my doctor's advice, my menstrual cycle became regular and my pain disappeared, which is quite pleasing.
Read More
9.5
Reduced chest pain
I noticed an improvement after giving my mother Rokushinmaru for her chest pain. She rarely complains about it now and takes the supplement less frequently. For her blood vessels, I've also provided additional vitamins K and D. She remains in good health even in her 70s.
Read More
8.8
Eased menstrual pain
Good gynaecologists now recommend methylfolate over folic acid, as it absorbs better. I've noticed a regular cycle and significantly less pain during my periods after just one jar. I believe this vitamin is effective!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
8
Folic acid improves angina symptoms
Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
Study directly assesses folic acid
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Read More
7
Folate's mixed effects on angina
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Lower relevance due to complexity
We explored the effects of folate treatment on a woman diagnosed with stable angina and a history of miscarriages, driven by hyperhomocysteinemia linked to the MTHFR C677T polymorphism. Her condition raised questions about whether supplementing with folic acid, along with vitamins B6 and B12, could alleviate her chest pain and improve her overall health.
Upon starting this combined treatment, we observed a notable 28.6% decrease in her homocysteine levels within two months. While this might suggest a positive trend towards her cardiovascular health, it's essential to highlight that despite the initial improvements, evidence regarding the long-term benefits of folate supplementation specifically for reducing chest pain has yet to be established.
Thus, while the vitamins showed effectiveness in lowering homocysteine levels, their role in significantly preventing future cardiovascular events remains uncertain. We acknowledge that further research will be necessary to better understand the broader implications of folate and its potential impact on conditions like angina and the associated risks.
Upon starting this combined treatment, we observed a notable 28.6% decrease in her homocysteine levels within two months. While this might suggest a positive trend towards her cardiovascular health, it's essential to highlight that despite the initial improvements, evidence regarding the long-term benefits of folate supplementation specifically for reducing chest pain has yet to be established.
Thus, while the vitamins showed effectiveness in lowering homocysteine levels, their role in significantly preventing future cardiovascular events remains uncertain. We acknowledge that further research will be necessary to better understand the broader implications of folate and its potential impact on conditions like angina and the associated risks.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
9.5
Reduced chest pain
I noticed an improvement after giving my mother Rokushinmaru for her chest pain. She rarely complains about it now and takes the supplement less frequently. For her blood vessels, I've also provided additional vitamins K and D. She remains in good health even in her 70s.
9.5
Guaranteed regularity
After starting folate on my doctor's advice, my menstrual cycle became regular and my pain disappeared, which is quite pleasing.
8.8
Eased menstrual pain
Good gynaecologists now recommend methylfolate over folic acid, as it absorbs better. I've noticed a regular cycle and significantly less pain during my periods after just one jar. I believe this vitamin is effective!
7.5
Reduced menstrual cramps
I didn’t notice significant changes, but my menstrual cramps improved remarkably after taking it, shifting from excruciating pain to mild cramping without pain.
3.5
Uncertain effects
I experienced muscle pain and some palpitations after taking it. I'm still unsure if it works since I didn’t take it regularly due to side effects.
